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Meaning
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Untimely ovarian failure is understood to be a first ovarian problem distinguisheded by absent menarche (prienorrhea) or premature exhaustion away from ovarian hair follicles/arrested folliculogenisis before the age of 40 years (additional amenorrhea) [step 1,2].
Epidemiology
POF influences everything: one in 10,000 women by the years 20; one out of step 1,000 female of the decades 29; one in 100 women of the age 40 . The fresh familial type of POF try uncommon, representing cuatro so you’re able to 31% of the many instances of POF [4-6].
Etiology
What causes POF are particularly heterogeneous. Received variations such as those taking place after treatment of neoplastic infection otherwise autoimmune ailment account fully for many cases . POF has an effective hereditary part which have X chromosome problems to relax and play a first part mainly on the circumstances with ovarian dysgenesis [7-10]. A gene (or genetics) to own POF (POF1) is localized so you’re able to Xq21.3–Xq27 on such basis as deletions in different people and you may household. One minute gene (or family genes) to own POF (POF2) accused from the study of healthy X/autosomal translocations has been localized to Xq13.3–q21.step one.